Custom Enzymes and Inhibitors
Cayman Chemical MLN4924, 905579-51-3, 1 mg
Molecular Formula C21H25N5O4S, Purity ≥98%, Formula Weight 443.5, Synonyms: Pevonedistat; An analog of adenosine 5'-monophosphate that selectively inhibits NAE (IC50 = 4.7 nM) and disrupts CRL-mediated protein turnover leading to apoptosis in cancer cells by deregulating S-phase DNA synthesis.
Cayman Chemical 17(R)-Resolvin D1, 528583-91-7, 25ug
Molecular Formula C22H32O5, Purity ≥95%, Formula Weight 376.5, Synonyms: 7S,8R,17R-trihydroxy-4Z,9E,11E,13Z,15E19Z-docosahexaenoic acid, Aspirin-triggered Resolvin D1, 17-epi-Resolvin D1, AT-RvD1, 17(R)-RvD1; An aspirin-triggered epimer of RvD1; reduces human leukocyte transendothelial migration (EC50 = ~30 nM), and limits leukocyte infiltration in a mouse model of peritonitis.
Cayman Chemical KT 5720, 108068-98-0, 50 µg
A potent inhibitor of PKA signaling that acts through competitive inhibition of ATP (Ki = 60 nM)
Cayman Chemical UNC1999, 1431612-23-5, 5 mg
A selective, cell-permeable EZH2 inhibitor (IC50 = 2 nM) that has been shown to inhibit H3K27methylation in MCF10A cells with an IC50 value of 124 nM
Cayman Chemical SB-431542, 301836-41-9, 10 mg
Molecular Formula C22H16N4O3, Purity ≥98%, Formula Weight 384.4; A potent and selective inhibitor of the TGF-1 receptor ALK5 (IC50 = 94 nM), ALK4 (IC50 = 140 nM) and, less effectively, ALK7; suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.